Metabolic Pathways Involved in Regulatory T Cell Functionality

Manipulating Immune Regulatory Pathways to Enhance T Cell Stimulation

Metabolic Regulation of Regulatory T Cell Development and Function

It is now well established that the effector T cell (Teff) response is regulated by a series of metabolic switches. Quiescent T cells predominantly require adenosine triphosphate-generating processes, whereas proliferating Teff require high metabolic flux through growth-promoting pathways, such as glycolysis. Pathways that control metabolism and immune cell function are intimately linked, and c...

Crosstalk between Metabolic and Regulatory Pathways

To enhance the understanding of cells’ response in a specific condition, one requires information that shows the interconnected view of biological process. Broadly speaking, biological pathways fall into two functional categories: metabolic and regulatory pathways. Existing pathway databases are categorizing specific pathway types according to their own definition about their own subject. They ...

Generalized Representation of Metabolic and Regulatory Pathways

Regulatory T Cells in Colorectal Cancer

One of the essential protection mechanisms of immune system is Treg cells which play an important role in maintenance ofimmune homeostasis. However, they may also inhibit immune functions against tumor cells. It has been reported that Treg cellsare increased in patients suffering from different types of cancer. Increased number of Treg cells has been shown in tumor lymphnodes, peripheral blood,...